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Molecular Imaging and Biology Award for the study of MedUni Vienna at the World Molecular Imaging Congress

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(Vienna, 04-10-2019) A cooperative study of MedUni Vienna was distinguished with the Molecular Imaging and Biology Award in the category "Best Clinical Paper" at the World Molecular Imaging Congress in Montréal.

The award went to the study "Changes in Tumour Biology During Chemoradiation of Cervix Cancer Assessed by Multiparametric MRI and Hypoxia PET" (Petra Georg, Piotr Andrzejewski, Pascal Baltzer, Michaela Daniel, Wolfgang Wadsak, Markus Mitterhauser, Alina Sturdza, Katarina Majercakova, Georgios Karanikas, Richard Pötter, Marcus Hacker, Thomas Helbich, Dietmar Georg, Katja Pinker).

The study was created as a cooperation of researchers between the University Clinics of Radio-oncology, Radiology and Nuclear Medicine as well as the Christian Doppler Laboratory for Medical Radiation research.

About the study
Various key processes of the creation of cervix cancer can be examined non-invasively with the multiparametric magnetic resonance tomography/ positron emission tomography (PET/MRI). Changes of tumour blood supply, cell density and particularly tumour-low oxygen level affect the therapy approach and thus provide valuable information for therapy planning, follow-up and prognosis.

This prospective study included patients with cervix cancer. The researchers examine the space-time stability of tumour-low oxygen level, blood supply and cell density by way of multi-parametric PET/MRI with a low oxygen level-specific radio tracer at four points in time: prior to therapy, during and after the start of the treatment with radio chemotherapy.

While the tumour blood supply and cell density decreased under therapy, interesting and unexpected changes in the tumour oxygen supply were observed. The longitudinal PET/MRT imaging thus allowed a non-invasive in-vivo characterisation of cervix cancer prior to, during and after radio chemotherapy and has the potential of contributing significantly to the therapy planning and follow-up in the future.

Service: Molecular Imaging and Biology
Changes in Tumour Biology During Chemoradiation of Cervix Cancer Assessed by Multiparametric MRI and Hypoxia PET
Petra Georg, Piotr Andrzejewski, Pascal Baltzer, Michaela Daniel, Wolfgang Wadsak, Markus Mitterhauser, Alina Sturdza, Katarina Majercakova, Georgios Karanikas, Richard Pötter, Marcus Hacker, Thomas Helbich, Dietmar Georg, Katja Pinker
Mol Imaging Biol. 2018 Feb;20(1):160-169. doi: 10.1007/s11307-017-1087-5.